L-glutathione concentrations in human tissues are associated with human health and aging. People who are physically and mentally healthy and long-lived have higher levels of glutathione in their blood tissue, in contrast, older adults with arthritis, diabetes or heart disease have lower levels of glutathione than those without disease, cancer and urinary Glutathione concentrations are significantly reduced in chronic patients with reproductive, gastrointestinal, cardiovascular, and musculoskeletal disorders.
Changes in L-glutathione Reduced concentrations in body tissues are associated with a range of inflammatory and neurodegenerative diseases and diseases such as cancer. Glutathione deficiency has been documented in various lung diseases such as acute respiratory distress syndrome, asthma and chronic obstructive pulmonary disease. Liver disease (fatty liver, acute and chronic hepatitis, cirrhosis) is also associated with decreased glutathione. Depletion of glutathione in vitro inhibits immune cell function, and intracellular glutathione plays a central role in the normal function of immune cells. Therefore, glutathione supplementation is recommended as an adjunct therapy.
